Tranexam is a drug used to stop and prevent bleeding of various etiologies.
The drug has a local and general hemostatic effect in bleeding associated with increased fibrinolysis (platelet pathology, menorrhagia). Additionally, tranexamic acid in the composition of Tranexam is characterized by effective anti-allergic, anti-inflammatory, anti-infective and anti-tumor effects based on the inhibition of active peptides involved in inflammatory and allergic reactions.
It is produced in the form of tablets and solution for injections (injections), the main active substance is tranexamic acid.
Clinical and pharmacological group
Tablets have antifibrinolytic, hemostatic, antiallergic and anti-inflammatory effects.
Terms of sale from pharmacies
Can buy by prescription.
Price
How much does Tranexam cost in pharmacies? The average price is at the level of 270 rubles.
Composition and form of release
Tranexam is produced in the form of tablets and solution for injection into a vein. Tablets containing the active ingredient 250 and 500 mg are packaged in contour cells of 10 pieces, 1, 2, 3, 5 cells per pack.
- Each tablet contains 250 mg or 500 mg of the active ingredient - Tranexamic acid, and also contains a number of auxiliary components.
pharmachologic effect
Tranexam is a fibrinolysis inhibitor, a hemostatic drug. This drug inhibits the conversion of plasminogen to plasmin.
Tranexamic acid in bleeding caused by fibrinolysis exhibits a systemic and local hemostatic effect. In addition, it has anti-allergic, anti-inflammatory, antitumor and anti-infective effects, which are based on the suppression of the formation of active peptides that are involved in inflammatory and allergic reactions.
The potentiating effect of tranexamic acid in relation to the analgesic activity of opiates and its own analgesic activity have been confirmed experimentally.
When taken orally, up to 50% of the drug is absorbed, the maximum concentration is reached after three hours. It binds to plasma proteins, crosses the placental barriers, is excreted in breast milk at a concentration of 1%. Acts for 17 hours in tissues, 7-8 hours in plasma. In case of impaired renal function, there is a risk of accumulation of the active substance. When administered intravenously, the analgesic activity of the drug was confirmed.
Indications for use
The drug is prescribed to patients for the treatment or prevention of disorders of the circulatory system, namely:
- Bleeding or the risk of their development with increased generalized fibrinolysis: manual separation of the placenta, postpartum hemorrhage, malignant tumors of the prostate and pancreas, liver disease, surgical interventions on the chest, leukemia.
- Bleeding or the risk of their development with increased local fibrinolysis: hematuria, gastrointestinal, uterine (including von Willebrand's disease and other coagulopathies) and nosebleeds, as well as bleeding after prostatectomy, conization of the cervix in carcinoma, tooth extraction in patients with hemorrhagic diathesis.
Tranexam capsules are also used for such diseases:
- Bleeding during pregnancy;
- Allergic diseases (allergic dermatitis, eczema, urticaria, toxic and drug rash);
- Hereditary angioedema;
- Inflammatory diseases (aphthae of the oral mucosa, stomatitis, pharyngitis, tonsillitis, laryngitis).
Solution for intravenous administration is also used in the following cases:
- Operations on the bladder;
- Surgical interventions for systemic inflammatory reactions (pancreatic necrosis, sepsis, peritonitis, severe or moderate preeclampsia, shock of various etiologies and other critical conditions).
Tranexam for uterine bleeding
There are many cases when uterine bleeding caused iron deficiency, which is also a threat to human health and life. Therefore, with uterine bleeding, hemostatic tablets are prescribed, including Tranexam. Of course, this should not be done without a doctor's prescription, since it is important to establish the causes of the violation, which can be very different.
Contraindications
Absolute:
- subarachnoid hemorrhage;
- hypersensitivity to the components of the drug.
Relative (Tranexam is used with caution):
- thrombosis (myocardial infarction, thromboembolic syndrome, deep vein thrombophlebitis);
- thrombohemorrhagic complications (in combination with indirect anticoagulants and heparin);
- kidney failure;
- hematuria from the upper urinary tract;
- color vision disorders.
Appointment during pregnancy and lactation
The drug Tranexam during pregnancy is prescribed to women according to indications, only if the benefit to the mother outweighs the possible risks to the fetus. Treatment is prescribed in the minimum effective dose, while constantly monitoring blood test results.
During clinical trials, no teratogenic and embryotoxic effects of Tranexam on the fetus were established, but the drug easily crosses the placental barrier.
The use of the drug during breastfeeding is not recommended. If therapy is necessary, it is advisable to stop lactation so as not to harm the child.
Dosage and method of application
As indicated in the instructions for use, Tranexam tablets are taken:
- With recurring nosebleeds three times a day, 1.0 g for 7 days;
- With uterine bleeding - 1.0 g every six hours for three days;
- After tooth extraction in patients with hemorrhagic diathesis, for the prevention of secondary bleeding, Tranexam tablets are prescribed at the rate of 25 mg / kg 4 times a day for a week;
- For the treatment of hereditary angioedema, the drug is prescribed in courses or constantly at 1.0 g twice a day;
- In the postoperative period, 1.5 g three times a day for 10-14 days.
Tranexam for intravenous drip or jet administration is usually used to stop massive bleeding, as well as bleeding that occurs during surgery. Before tooth extraction, patients with impaired blood clotting are also administered the drug intravenously, and after extraction, Tranexam is prescribed in tablets.
Side effects
Against the background of treatment with the drug in ampoules and tablets, the following may appear:
- allergy, which is manifested by a rash, skin itching and urticaria;
- thromboembolism and thrombosis;
- loss of appetite up to anorexia, loose stools, heartburn, nausea and vomiting;
- vertigo, drowsiness, disorder of color perception and color vision.
When prescribing the drug in ampoules, the following undesirable reactions may occur:
- increased heart rate;
- chest pains;
- pressure drop.
Overdose
Data on drug overdose are not provided.
special instructions
Before starting Tranexam and during treatment, regular examinations by an ophthalmologist are recommended for the diagnosis of visual acuity, the condition of the fundus, and color perception.
During pregnancy, the drug is used with caution (contraindications must be taken into account). When prescribing tranexamic acid to pregnant and lactating women, it must be taken into account that this substance is able to pass through the placental barrier and enter breast milk.
Interaction with other drugs
With simultaneous use with hemocoagulase and hemostatic agents, thrombus formation can be activated.
Tranexam solution is pharmaceutically incompatible with urokinase, blood products, tetracyclines, diazepam, dipyridamole, hypertensive drugs (metformin bitartrate, deoxyepinephrine hydrochloride, norepinephrine) and solutions containing penicillin.
I had a chance to get acquainted with these tablets about a year ago. I still use them from time to time, but I still can’t really understand how tranexam works, because in my case it doesn’t always work equally effectively.
The gynecologist prescribed tranexam for me during bleeding, which most likely arose due to the growth of fibroids against the background of hormonal changes. The story, I believe, is quite common among adult aunts, and everyone wants to find suitable means to cope with such conditions: otherwise, the matter may turn into an operation, no matter how sad it may be.
Issue price.
I would not call tranexam a budget tool: the cost of packaging from 10 tablets- near 250 rubles, from 30 tablets - about 550 rubles. It is more profitable to buy, of course, a large package, but at first only one record was bought:
The tablets are small, tasteless and odorless, so there were no problems with taking:
How to drink tranexam?
I was given this scheme:
Tranexam: 1 tablet 3 times a day - for 3-5 days;
Nimesil: 1 powder 2 times a day - for 3 days.
During the first course, two points emerged: good and bad.
I'll start with the good - side effects from taking tranexam in general did not arise, although at first there were doubts about whether the tranexam could save the father of Russian democracy for me. Since I tolerated the remedy quite normally, without side effects, a little later I bought a box of 30 tablets to last for 5 days (and then left):
It turns out that the drug is produced in Russia(I wouldn't think so based on the price):
The bad thing was that with the help of tranexam stop the bleeding for the 5 days indicated by the doctor to me failed(I didn’t start taking it from the first day - it took some time before I sounded the alarm and asked for help); thus, the process dragged on for almost two weeks, and I began to call my gynecologist in a panic.
After listening to my complaints, the doctor kindly offered to "go to the hospital for a cleaning", but since I did not show much enthusiasm, I was prescribed injections of dicynone after (this thing, by the way, helped very quickly).
Despite such an action of tranexam (or inaction?), From its reception in the future I Not refused. Due to the fact that the cycle has been famously “dancing” lately, you will never guess what all this will result in: in a couple of days or two weeks, or even more. I was recommended constantly have a couple tranexam-nimesil and start taking medication as soon as spotting occurs.
I had to resort to this scheme several times during the year. in situations where I was sure that I would not be able to see a doctor in time if necessary(for example, when I or my doctor go on vacation, or when the whole country has a long and happy rest during the holidays). I don’t know if it is possible to take tranexam once a month (or even more often) for a long time, and even in combination with NSAIDs, so I try not to abuse it, but under certain circumstances you have to choose the lesser of two evils.
According to my observations, if you start taking tranexam immediately, on the day the bleeding starts, then there is a chance to get by with little blood and meet the standard 5-7 days. In any case, tranexam helps me with heavy periods much better than nettle with a shepherd's purse, and it is much more convenient to use than brewing herbs, especially when traveling.
By the way, Tranexam's storage conditions are very nice to me: in the summer you can keep it right in your bag just in case.
The box indicates that the drug is prescription, but you can buy tranexam at any pharmacy without any problems.
- it is the prerogative of doctors;
- the cost of tranexam is not the most humane;
- I still don't really understand how effective the drug works. (To reiterate, in my experience, tranexam does NOT help with bleeding if you miss the moment, and does a good job when you start taking it immediately).
In general, this tranex seemed to me to be some kind of ambiguous remedy. The instructions below are for those who are interested in the details, but it is better to talk with your doctor.
Bleeding, as a complication of various diseases, in some cases is fatal for a person if help is not provided in time. Tranexam can deal with this problem. The main substance in its composition is able to activate the action of platelets and thereby stop bleeding. Below is a detailed instruction on the use of Tranexam: characteristics of the drug, its action, composition, contraindications, side effects, methods of use.
Characteristics of the drug
Produced in the form of tablets and solution for injection.
- Pills. Outside covered with a shell of a light shade, round, biconvex shape. On the cut, the core and shell have a shade from white to cream.
- Solution. It is a transparent liquid. May change color to brown.
The composition of the drug
It is represented by the active (basic) substance - tranexamic acid. The dosage for one tablet is 250 mg, for the liquid form - 50 mg / ml.
- Additional components: for tablets - hyprolose, cellulose, talc, calcium stearate, silicon dioxide, sodium carboxymethyl starch; for ampoules - water (1000 ml).
- Additional components of the shell: for tablets - titanium dioxide, talc, macrogol, hypromellose.
How does it affect the body?
It belongs to the hemostatic group, that is, it has hemostatic properties. Slows down the course of the chemical reaction of fibrinolysis. This is the process that contributes to the destruction of the blood clot. Resists the synthesis of plasminogen and its conversion to plasmin protein.
In addition, the drug can suppress allergic, inflammatory processes. This is due to the ability of the drug to inhibit the formation of kinins. These polypeptides play a large role in enhancing the inflammatory phenomenon.
In the course of the study, the analgesic (analgesic) effect of the active substance was proven.
How is it distributed in the body?
Absorption, distribution in tissues, excretion of the drug are considered.
Absorption
When taken in a dosage of not more than 2-3 grams, absorption in the body is 50%. Its maximum concentration is found in 3-4 hours. As a result, inside the body, the acid undergoes medium absorption, slightly connecting with the blood plasma.
Distribution in tissues
The same throughout the body. Otherwise, the situation is in the cerebrospinal fluid. There it is concentrated in a ratio of 1 to 10 of the serum level.
Passes through the placental barrier and is found in breast milk. The presence of acid can also be seen in seminal fluid, but it does not significantly affect sperm motility.
The hemostatic effect persists in the tissues for 16-18 hours, in the blood - 6-9 hours.
Metabolism and excretion
It is excreted through the kidneys in almost unchanged form for 11-14 hours. With functional disorders of the organ, taking the drug leads to the accumulation of the active substance.
Pills
The main reason for prescribing Tranexam tablets is bleeding. It may be caused by the reasons listed below.
Bleeding with local fibrinolysis:
- bleeding from the uterine cavity,
- gastrointestinal bleeding,
- bleeding from the nose,
- with various interventions on the cervix,
- after tooth extraction
- hematuria,
- after a prostatectomy.
Bleeding with fibrinolysis of a generalized nature:
- tumor processes, more often in the prostate, pancreas,
- operations in the sternum,
- leukemia,
- liver disease.
Other forms:
- bleeding during pregnancy;
- allergic reactions (dermatitis, eczema, etc.);
- inflammatory processes (larynx, pharynx, oral cavity, etc.);
- angioedema (Quincke's edema).
intravenous solution
Appointed in the following situations:
- bleeding due to fibrinolysis;
- operations on internal organs;
- interventions in inflammatory processes (sepsis, gestosis, damage to the pancreas, peritonitis, etc.).
The drug is prescribed for children 12 years of age and older, but in extreme cases . This may be uterine bleeding in girls during the onset of the first menstruation.
Contraindications
Tranexam, like every drug, has contraindications. This is indicated in the instructions for the medicine.
- In tablets: in case of intracranial hemorrhage and individual intolerance to the components of the drug.
- In ampoules: while taking penicillin and using medications that help lower blood pressure.
The drug should be taken with caution in such cases:
- thrombosis (necrosis of a portion of the myocardium, blockage of cerebral vessels, the formation of a blood clot in the veins);
- renal failure (the threat of accumulation in the kidneys of the active substance);
- thrombohemorrhagic phenomena (when combined with anticoagulants);
- violation of color perception;
- hematuria of the urinary tract.
Methods of application are different depending on the cause of bleeding.
Application of Traneksam in tablets:
Cause | Dosage (g) | Reception frequency |
1-1,5 | 2 to 3 times during the day | |
Bleeding from the uterine cavity | 1-1,5 | 3 to 4 times over 4-5 days |
Bleeding from the nasal cavity | 1 | 3 times in 6 days |
Operations on the cervix | 1,5 | From 3 times within 13-14 days |
Quincke's edema | 1-1,5 | 2 to 3 times regularly or intermittently, depending on possible side effects |
Bleeding during pregnancy | 0,25-0,5 | From 3-4 times until the bleeding stops completely. |
inflammation and allergies | 1-1,5 | From 2 to 3 times within 4-9 days, taking into account the complexity of the process |
Fibrinolysis of hemolyzed character* | 1-1,5 | 2 to 3 times during the day |
Hole bleeding (as a result of tooth extraction) | 1-1,5 | 3 to 4 times over 6-9 days |
pseudohemophilia | 1-1,5 | 3 to 4 times over 3-10 days |
With heavy periods | 250 | 3-4 times starting from the first day of the female cycle |
Solution for injection (intravenous):
Fibrinolysis of a hemolyzed nature | 15 mg/kg | Regularly, every 6-8 hours |
fibrinolysis of a local nature | 0,25-0,5 | 2-3 times during the day |
Surgery on the bladder or prostate | During operation 1 g | |
After surgery 1 g | Constantly, with an interval of 7-9 hours for 3 days | |
widespread inflammatory process | 10-11 mg/kg | 20-30 minutes before surgery |
* With hemolyzed fibrinolysis, in the reviews of doctors, injections are recommended first with a smooth transition to the form in the form of tablets.
kidney disease
In renal failure, a dose change is indicated. If creatinine is detected in the blood, not exceeding 150 µmol / l - 1000 mg up to two times a day, not more than 500 µmol / l - 1000 mg once a day, exceeding 500 µmol / l - 500 mg once a day.
The exact dosage is determined by the attending physician. It is forbidden to use the drug on its own.
What can happen after taking?
Tranexam can adversely affect the functioning of the body.
- When taking tablets from the digestive system, vomiting, nausea, burning in the larynx, loss of appetite are sometimes observed.
- Nervous system: there is weakness, dizziness.
- Sense organs: violation of color perception.
- Organs of hematopoiesis: thrombosis, acute blockage of blood vessels (rarely).
If side effects occur, stop taking the drug and consult a doctor.
Combination with other drugs
When taken simultaneously with some other drugs, adverse reactions may develop.
- Hemostatic drugs. When combined with other hemostatic drugs, the process of thrombus formation is enhanced.
- Traneksam in the form of ampoules. Not compatible with products containing penicillin, urokinase. Incompatible with drugs that increase blood pressure: tetracyclines, diazepam, dipyridamole. Under supervision, it should be taken in combination with anticoagulants, heparin, because there is a possibility of thrombohemorrhagic complications.
- Tranexam and spirits. Ethyl alcohol during administration thins the blood, which reduces the therapeutic effect of the drug to zero. In the future, when ethanol is removed from the body, the blood begins to thicken. With the simultaneous intake of alcohol with a medication, blockage of blood vessels is likely, which leads to death. Also, alcohol increases blood pressure, which provokes a hypertensive crisis. Therefore, it is strictly forbidden to take Tranexam and alcohol at the same time.
Taking during pregnancy
The drug can be taken by women in a position under the strict supervision of a physician. Nursing mothers need to be aware that the drug crosses the barrier and is found in breast milk. The study did not reveal a negative effect on fetal development during pregnancy.
- Experts do not recommend taking Tranexam for women for more than three menstrual cycles in a row.
- Before starting treatment, it is advisable to visit an ophthalmologist to check vision, fundus and color perception.
Medicine analogs
Medicines that are similar in composition are identified by their international non-proprietary name (INN). Tranexam analogues:
- Dicynon;
- Hamamelis;
- Contriven;
- Vilate and others.
Release form
Produced in the form of tablets and solution.
- Pills. Sheathed. Dosage 250 and 500 mg. The package contains 10 tablets.
- Injection in ampoules. In clear glass ampoules, 5 ml. Special forms contain 5 pcs. In a hard pack 1 or 2 special packages.
Medication cost
How much does the drug cost? According to data for 2016, the cost in tablet form (10 tablets of 250 mg) varies from 200 to 250 rubles, depending on the region of Russia, in liquid form (10 pieces of 5 ml) - from 1600-1900 rubles.
The effectiveness of the drug Tranexam
Given the benefits of the drug and possible side effects, it can be concluded that Tranexam is an effective drug for stopping bleeding for various reasons. A big plus is that it is allowed to be used by pregnant women and girls with menstrual irregularities, because a healthy woman is a healthy generation.
Positive results are also observed in the reviews of people who are sick with cancer of the uterus, pancreas, prostate. But, as with other drugs, self-medication is inappropriate here, since the body of each person is individual and it reacts differently.
In general, based on the composition of the drug, its benefits, positive feedback from people who drank the drug, there is reason to trust Tranexam as an effective tool in the fight against bleeding.
In this article, you can read the instructions for using the drug Tranexam. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Tranexam in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Tranexam analogues in the presence of existing structural analogues. Use for the treatment of bleeding during surgery, during menstruation in adults, children, as well as during pregnancy and lactation.
Tranexam- hemostatic drug. fibrinolysis inhibitor. Specifically inhibits the activation of plasminogen and its conversion to plasmin. It has a local and systemic hemostatic effect in bleeding associated with an increase in fibrinolysis (platelet pathology, menorrhagia).
By suppressing the formation of kinins and other active peptides involved in allergic and inflammatory reactions, it has anti-allergic and anti-inflammatory effects.
Experimental studies have confirmed the intrinsic analgesic activity of tranexamic acid, as well as a potentiating effect on the analgesic activity of opioid analgesics.
Compound
Tranexamic acid + excipients.
Pharmacokinetics
When taken orally at a dose of 0.5-2 g, 30-50% of the drug is absorbed. It is distributed relatively evenly in tissues (with the exception of the cerebrospinal fluid, where the concentration is 1/10 of the plasma). Penetrates through the placental barrier and the blood-brain barrier (BBB), excreted in breast milk (reaching approximately 1% of the concentration in the mother's plasma). It is found in seminal fluid, where it reduces fibrinolytic activity, but does not affect sperm migration. It is excreted by the kidneys (the main route is glomerular filtration), more than 95% unchanged during the first 12 hours.
Indications
- bleeding or the risk of bleeding against the background of a generalized increase in fibrinolysis (bleeding during surgery and in the postoperative period, postpartum bleeding, manual separation of the afterbirth, chorionic detachment, bleeding during pregnancy, malignant neoplasms of the pancreas and prostate, hemophilia, hemorrhagic complications of fibrinolytic therapy, thrombocytopenic purpura , leukemia, liver disease, prior streptokinase therapy);
- bleeding or the risk of bleeding against the background of local enhancement of fibrinolysis (uterine, nasal, gastrointestinal bleeding, hematuria, bleeding after prostatectomy, conization of the cervix for carcinoma, tooth extraction in patients with hemorrhagic diathesis);
- hereditary angioedema (for tablets);
- allergic diseases, incl. eczema, allergic dermatitis, urticaria, drug and toxic rash (for tablets);
- inflammatory diseases of the oral cavity and pharynx, including tonsillitis, pharyngitis, laryngitis, stomatitis, aphthae of the oral mucosa (for tablets);
- surgical interventions on the bladder (for solution);
- surgical manipulations with a systemic inflammatory reaction, incl. sepsis, peritonitis, pancreatic necrosis, severe and moderate preeclampsia, shock of various etiologies (for solution).
Release form
Film-coated tablets 250 mg and 500 mg.
Solution for intravenous administration (injections in ampoules for injection).
Instructions for use and dosage
Pills
The drug is prescribed inside.
With local fibrinolysis, 1-1.5 g is prescribed 2-3 times a day.
With profuse uterine bleeding, 1-1.5 g is prescribed 3-4 times a day for 3-4 days.
With bleeding on the background of von Willebrand's disease and other coagulopathy - 1-1.5 g 3-4 times a day for 3-10 days.
After cervical conization surgery - 1.5 g 3 times a day for 12-14 days.
With nosebleeds - 1 g 3 times a day for 7 days.
Patients with coagulopathy after tooth extraction - 1-1.5 g 3-4 times a day for 6-8 days.
When bleeding during pregnancy, it is prescribed - 250-500 mg 3-4 times a day until the bleeding stops completely. The average duration of the course of treatment is 7 days.
With hereditary angioedema - 1-1.5 g 2-3 times a day continuously or intermittently, depending on the presence of prodromal symptoms.
With symptoms of allergies and inflammation - 1-1.5 g 2-3 times a day for 3-9 days, depending on the severity of the condition.
With generalized fibrinolysis, therapy begins with parenteral intravenous administration, followed by a transition to oral administration at a dose of 1-1.5 g 2-3 times a day.
Ampoules
Intravenously (drip (dropper), jet). In case of generalized fibrinolysis, a single dose of 15 mg/kg of body weight is administered every 6-8 hours, the rate of administration is 1 ml/min. With local fibrinolysis, it is recommended to administer the drug at a dose of 250-500 mg 2-3 times a day. For prostatectomy or bladder surgery, 1 g is administered during surgery, then 1 g every 8 hours for 3 days, after which they switch to ingestion of a tablet form until gross hematuria disappears.
With a high risk of bleeding, with a systemic inflammatory reaction at a dose of 10-11 mg / kg 20-30 minutes before the intervention.
Patients with coagulopathy before extraction of the tooth are administered at a dose of 10 mg/kg of body weight, after extraction of the tooth, oral administration of the tablet form of the drug is prescribed.
In case of violation of the excretory function of the kidneys, a correction of the dosing regimen is necessary: at a creatinine concentration in the blood of 120-250 μmol / l, 10 mg / kg are prescribed twice a day; at a creatinine concentration of 250-500 µmol/l, 10 mg/kg is prescribed once a day; at a creatinine concentration of more than 500 µmol / l, 5 mg / kg is prescribed once a day.
Side effect
- anorexia;
- nausea, vomiting;
- heartburn;
- diarrhea;
- dizziness;
- weakness;
- drowsiness;
- violation of color perception;
- blurred vision;
- thrombosis and thromboembolism;
- tachycardia;
- chest pain;
- arterial hypotension (with rapid intravenous administration);
- skin rash;
- hives.
Contraindications
- subarachnoid hemorrhage;
- hypersensitivity to the components of the drug.
Use during pregnancy and lactation
It is used during pregnancy according to indications with the obligatory consideration of contraindications, tranexamic acid crosses the placental barrier and is excreted in breast milk (reaching approximately 1% of the concentration in the mother's plasma).
special instructions
Before and during treatment, it is necessary to conduct examinations by an ophthalmologist for visual acuity, color perception, and the condition of the fundus.
drug interaction
When combined with hemostatic drugs and hemocoagulase, activation of thrombus formation is possible.
The solution for intravenous administration is pharmaceutically incompatible with blood products, solutions containing penicillin, urokinase, hypertensive agents (norepinephrine, deoxyepinephrine hydrochloride, metharmine bitartrate), tetracyclines, dipyridamole, diazepam.
Caution should be used in combination with heparin and anticoagulants in patients with coagulation disorders and thrombosis (cerebrovascular thrombosis, myocardial infarction, thrombophlebitis) or the threat of their development.
Tranexam's analogues
Structural analogues for the active substance:
- Tranexamic acid;
- Transamcha;
- Troxaminate;
- Exacyl.
Analogues by pharmacological group (fibrinolysis inhibitors):
- Amben;
- Aminocaproic acid;
- Aprotex;
- Aprotinin;
- Aerus;
- Vero Narcap;
- Gordox;
- Gumbix;
- Ingitril;
- Contrykal;
- Pamba;
- Polycapran;
- Trasilol 500000;
- Traskolan.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.
Do you have heavy and painful periods, or worse, are you in danger of miscarriage? In this case, the doctor can prescribe an effective remedy for Traneksam. These are pills, the action of which is aimed at stopping bleeding. Today we learn the opinions of patients about the drug "Tranexam" with heavy periods. Reviews of women who have experienced the threat of miscarriage will also be considered. And of course, we will learn about the side effects and contraindications in taking this medication.
Indications for use. international name
Tranexam tablets, flattering reviews of which are left by both the patients themselves and experienced doctors, can be prescribed under the following circumstances:
Bleeding during pregnancy.
Individual intolerance to the drug.
With extreme caution, Tranexam tablets for bleeding, reviews of which are left by many women, should be used in the treatment of patients with myocardial infarction, deep vein thrombosis or cerebral vessels. Also, this medicine should be used carefully in patients who have renal insufficiency.
Price
Despite the fact that the price of many drugs has recently increased, Traneksam is still quite affordable. So, for 10 tablets of this medicine, you need to pay about 200 rubles. This is not much money, given the positive effect achieved after therapy with this remedy.
Now you know what medicine the doctor can prescribe for heavy menstruation, as well as uterine bleeding, leading to miscarriage. We found out that Tranexam has mostly positive feedback from patients. This means that it really brings results. True, self-medication in this case is strictly prohibited. Only a doctor can prescribe Tranexam medicine.